Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome
Identifieur interne : 001E58 ( Main/Exploration ); précédent : 001E57; suivant : 001E59Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome
Auteurs : Y. A. Dalavanga [Grèce] ; P. V. Voulgari [Grèce] ; A. N. Georgiadis [Grèce] ; C. Leontaridi [Grèce] ; S. Katsenos [Grèce] ; M. Vassiliou [Grèce] ; A. A. Drosos [Grèce] ; S. H. Constantopoulos [Grèce]Source :
- Rheumatology International [ 0172-8172 ] ; 2006-07-01.
English descriptors
- KwdEn :
Abstract
Abstract: Twelve years ago we reported that lymphocytic alveolitis [or bronchoalveolar lavage (BAL) lymphocytosis] correlates with clinical pulmonary involvement in primary Sjogren’s syndrome (pSS). Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.
Url:
DOI: 10.1007/s00296-005-0092-1
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000803
- to stream Istex, to step Curation: 000803
- to stream Istex, to step Checkpoint: 000D08
- to stream Main, to step Merge: 001E72
- to stream Main, to step Curation: 001E58
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title><author><name sortKey="Dalavanga, Y A" sort="Dalavanga, Y A" uniqKey="Dalavanga Y" first="Y. A." last="Dalavanga">Y. A. Dalavanga</name></author><author><name sortKey="Voulgari, P V" sort="Voulgari, P V" uniqKey="Voulgari P" first="P. V." last="Voulgari">P. V. Voulgari</name></author><author><name sortKey="Georgiadis, A N" sort="Georgiadis, A N" uniqKey="Georgiadis A" first="A. N." last="Georgiadis">A. N. Georgiadis</name></author><author><name sortKey="Leontaridi, C" sort="Leontaridi, C" uniqKey="Leontaridi C" first="C." last="Leontaridi">C. Leontaridi</name></author><author><name sortKey="Katsenos, S" sort="Katsenos, S" uniqKey="Katsenos S" first="S." last="Katsenos">S. Katsenos</name></author><author><name sortKey="Vassiliou, M" sort="Vassiliou, M" uniqKey="Vassiliou M" first="M." last="Vassiliou">M. Vassiliou</name></author><author><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. Drosos</name></author><author><name sortKey="Constantopoulos, S H" sort="Constantopoulos, S H" uniqKey="Constantopoulos S" first="S. H." last="Constantopoulos">S. H. Constantopoulos</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:92070722C099F3FEA3FBC887BF314072F05F2335</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1007/s00296-005-0092-1</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000803</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000803</idno><idno type="wicri:Area/Istex/Curation">000803</idno><idno type="wicri:Area/Istex/Checkpoint">000D08</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D08</idno><idno type="wicri:doubleKey">0172-8172:2005:Dalavanga Y:lymphocytic:alveolitis:a</idno><idno type="wicri:Area/Main/Merge">001E72</idno><idno type="wicri:Area/Main/Curation">001E58</idno><idno type="wicri:Area/Main/Exploration">001E58</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title><author><name sortKey="Dalavanga, Y A" sort="Dalavanga, Y A" uniqKey="Dalavanga Y" first="Y. A." last="Dalavanga">Y. A. Dalavanga</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Anatomy, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Voulgari, P V" sort="Voulgari, P V" uniqKey="Voulgari P" first="P. V." last="Voulgari">P. V. Voulgari</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Georgiadis, A N" sort="Georgiadis, A N" uniqKey="Georgiadis A" first="A. N." last="Georgiadis">A. N. Georgiadis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Leontaridi, C" sort="Leontaridi, C" uniqKey="Leontaridi C" first="C." last="Leontaridi">C. Leontaridi</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Katsenos, S" sort="Katsenos, S" uniqKey="Katsenos S" first="S." last="Katsenos">S. Katsenos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Vassiliou, M" sort="Vassiliou, M" uniqKey="Vassiliou M" first="M." last="Vassiliou">M. Vassiliou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. Drosos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Grèce</country></affiliation></author><author><name sortKey="Constantopoulos, S H" sort="Constantopoulos, S H" uniqKey="Constantopoulos S" first="S. H." last="Constantopoulos">S. H. Constantopoulos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatol Int</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2006-07-01">2006-07-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="799">799</biblScope><biblScope unit="page" to="804">804</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BAL lymphocytosis</term><term>Bronchoalveolar lavage</term><term>Epitheliitis</term><term>Lymphocytic alveolitis</term><term>Primary Sjogren’s syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Twelve years ago we reported that lymphocytic alveolitis [or bronchoalveolar lavage (BAL) lymphocytosis] correlates with clinical pulmonary involvement in primary Sjogren’s syndrome (pSS). Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</div></front></TEI><affiliations><list><country><li>Grèce</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Dalavanga, Y A" sort="Dalavanga, Y A" uniqKey="Dalavanga Y" first="Y. A." last="Dalavanga">Y. A. Dalavanga</name></noRegion><name sortKey="Constantopoulos, S H" sort="Constantopoulos, S H" uniqKey="Constantopoulos S" first="S. H." last="Constantopoulos">S. H. Constantopoulos</name><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. Drosos</name><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. Drosos</name><name sortKey="Georgiadis, A N" sort="Georgiadis, A N" uniqKey="Georgiadis A" first="A. N." last="Georgiadis">A. N. Georgiadis</name><name sortKey="Katsenos, S" sort="Katsenos, S" uniqKey="Katsenos S" first="S." last="Katsenos">S. Katsenos</name><name sortKey="Leontaridi, C" sort="Leontaridi, C" uniqKey="Leontaridi C" first="C." last="Leontaridi">C. Leontaridi</name><name sortKey="Vassiliou, M" sort="Vassiliou, M" uniqKey="Vassiliou M" first="M." last="Vassiliou">M. Vassiliou</name><name sortKey="Voulgari, P V" sort="Voulgari, P V" uniqKey="Voulgari P" first="P. V." last="Voulgari">P. V. Voulgari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E58 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E58 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:92070722C099F3FEA3FBC887BF314072F05F2335
|texte= Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome
}}
| This area was generated with Dilib version V0.6.33. |  |